基本情況
姓名:李桂銀
性別👨🏻🔧:女
出生年月🤓🧡:1972-10
籍貫:湖南省
職位👩🏻✈️:博士
職稱🙅♂️:教授
聯系方式
電話:18607732676
傳真:暫無資料
郵箱:liguiyin01@gdupt.edu.cn
通訊地址🙌🏻: 廣東省茂名市熊猫体育化學學院
郵編:525000
個人網站:
教育經歷
2004年-2008年中南大學化學化工學院功能材料所,獲工學博士學位📬;
2001年-2004年中南大學化學化工學院,獲理學碩士學位;
1992年-1995年邵陽學院化工工藝專業😳🔛,獲理學學士學位🥂。
工作經歷
2021.09-至今,熊猫体育化學學院二級教授✣,學科帶頭人
2010.10-2021.09,桂林電子科技大學生命與環境科學學院教授
2015.06-2016.07🪷🤱🏿,University of Michigan, Biomedical Engineering, Visiting Scholar
2014.01-2018.12,廣西醫科大學生物靶向診治中心臨床醫學博士後
2013.01-2014.01, 桂林電子科技大學生命與環境科學學院副院長
2008.12-2010.09,中南大學藥學院藥學博士後流動站藥學博士後
2004.04-2010.09, 湖南科技職業學院輕化工程學院副教授
講授課程
《化妝品生產工藝學》🤦,本科;
《精細化工概論》🧑🏿💻,本科;
《生物醫學傳感與檢測原理》,本科👳🏻🔉;
《藥理學(英文教材)》,本科;
《藥物化學》🈹,本科;
《生物材料》,本科🦽;
《生物力學》🧗🏻,本科🏯;
《生物信息學數據挖掘》,本科👨🏼🦲♠️;
《微生物與免疫學》,本科;
《生物材料》🚶🏻♀️➡️,研究生;
《高等分子生物學》👲🏽,研究生;
《醫學檢驗原理》,研究生。
科研方向
1. 重大疾病標記物的血清學檢測
2. 稀(貴)金屬的富集與去除
3. 生物醫學傳感
4. 納米靶向藥物的構築與評價
科研項目
1. 國家自然科學基金,硼氮摻雜碳點/二硫化鉬基納米酶熒光-電化學雙模同步邏輯傳感平臺檢測肝癌標誌物研究(62371143)2024-2027,主持,在研👩🏼💼。
2. 熊猫体育高層次人才引進項目,熒光-電化學雙信號傳感檢測GP73的研究(RC-XJ2022000401),2022-2027,主持,在研。
3. 國家自然科學基金,基於石墨烯的GPC3適配體納米生物傳感器靶向診斷肝癌的研究(81760534)👨👨👧👧🛌🏽,2018-2021,主持,結題。
4. 廣西壯族自治區科學技術廳, 廣西重點研發計劃(桂科AB18281013), 柿單寧提取製粉技術與重(貴)金屬捕集劑的研製與應用示範, 2019-2022, 160萬元, 子課題負責人,結題。
5. 國家自然科學基金,近紅外熒光/磁性Endoglin適配體靶向肺癌雙模態成像研究(81460451),2015-2018,主持,結題。
6. 廣西自然科學基金🕙,柿單寧/石墨烯/Pt-Pd無酶血糖傳感器研究(2016GXNSFAA380080),2016- 2019,主持,結題。
7. 中國博士後科學基金,基於Endoglin靶的光/磁探針用於肝癌多模態成像研究(2013M531916),2014-2016📮,主持,結題。
8. 廣西科技廳科學計劃與研究項目🧘🏼,柑桔果皮黃酮類及辛弗林生物活性物質高校提取關鍵技術研究(桂科轉1412200813),2014-2016,主持🧑✈️,結題。
9. 廣西科技廳科學計劃與研究項目,一種治療骨質增生、椎間盤突出的外敷藥的穩定化研究(桂科攻12300011)🧑🏿🌾⛴,2012-2016🧏🏽♀️,主持,結題。
10. 國家自然科學基金重點項目,特異性適配體生物傳感器靶向診斷肝癌的新技術研究 (81430055),2015-2019,主要參與,結題🛩。
獲獎情況
1. 廣西科學技術進步獎三等獎,超低成本五分類血細胞分析儀的研製,2020年;
2. 廣西醫藥衛生適宜技術推廣獎二等獎,基於啞鈴型Au-Fe3O4納米材料的生物傳感方法構建及其臨床應用🦠,2019年;
3. 廣西科學技術進步獎三等獎,基於磁納米金的生物傳感方法構建及其臨床應用, 2019年;
4. 廣西科技技術發明獎三等獎😫,柿單寧提取製粉技術及功能化應用,2018年;
5. 桂林電子科技大學生物醫學學科學術帶頭人,2014年;
6. 廣西高等教育自治區教學成果獎⬅️,廣西高等教育自治區教學成果獎🤠,校級👨🏼✈️,2012年;
7. 桂林電子科技大學學術骨幹🔩,2011年;
8. 湖南省“芙蓉百崗明星”,湖南省總工會♦️,2009年;
9. 湖南省普通高校中青年骨幹教師3️⃣,湖南教育廳,2008年。
論著一覽(2022-2023)
[1] Li Guiyin, Li Shengnan, Huang Qing, Li Xinhao, Zhang Zhengyu, Liang Jintao*, Zhou Zhide*. Rapid and specific detection of LDL based on light addressable potentiometric sensor decorated with reduced graphene oxide-polyaniline-hemin nanocomposites, Microchemical Journal 194 (2023) 109314.
[2] Li Guiyin, Li HaiMei, Li Xinhao, Huang Huapeng, Bian Huimin*, Liang Jintao*, Zhou Zhide*. A label-free electrochemical aptasensor for low-density lipoprotein detection using MoS2-Au-Fc nanosheets as a high-performance redox indicator, Microchemical Journal 193 (2023) 109068.
[3] Li Guiyin, Zhou Zhide, Wang Zhongmin, Chen hiwei, Liang Jintao, Yao Xiaoqing, Li Liuxun. An Efficient Electrochemical Biosensor to Determine 1,5-Anhydroglucitol with Persimmon-Tannin-Reduced Graphene Oxide-PtPd Nanocomposites, Materials, 16 (2023) 2786
[4] Li Guiyin,Wang Bo, Li Ling, Li, Xinhao, Yan Ruijie, Liang Jintao, Zhou Xinchun, Li Liuxun, Zhou Zhide. H-rGO-Pd NPs nanozyme enhanced silver deposition strategy for electrochemical detection of glypican-3, Molecules 28(5) (2023) 2271
[5] Liang Jintao, Yan Ruijie, Chen Chunguan, Yao Xiaoqing, Guo Fei, Wu Runqiang, Zhou Zhide*, Chen Jiejing*. Li Guiyin*. A novel fluorescent strategy for Golgi protein 73 determination based on aptamer/nitrogen-doped graphene quantum dots/molybdenum disulfide @ reduced graphene oxide nanosheets, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 294 (2023) 122538
[6] Liang Jintao, Yan Kaiteng, LiuYutong,Yao Xiaoqing, Guo Fei, Xue Wen, Li Guiyin*, Chen Jiejing*, Zhou Zhide*. A rGO-PAM-Fc/AuNPs nanosensing membrane in a light-addressable potentiometric biosensor for 1,5-anhydroglucitol determination, Microchemical Journal, 184 (2023) 108185.
[7] Wang Zhongmin, Liu Zhigao,Wu Chenxi, Liu Songlin, Wang Dianhui, Hu Chaohao, Chen Tao, Ran Zhaojin*, Gan Weijiang*, Li Guiyin*. Computational Analysis on Antioxidant Activity of Four Characteristic Structural Units from Persimmon Tannin, Materials, 16 (2023) 320
[8] Sun Xinjun, Fang Fengyan, Na Jintong, Yan Runjie, Huang Yong, Zhou Zhide*, Zhao Yongxiang*, Li Guiyin*, Fluorescent "turn-on" aptamer sensor for sensitive and reliable detection of Golgi glycoprotein 73 based on nitrogen-doped graphene quantum dots and molybdenum disulfide nanosheets, Journal of Pharmaceutical and Biomedical Analysis, 225 (2023) 115215
[9] Li Guiyin, Li Haimei, Wang Chaoxian, Li Xinhao, Chen Jiejing*, Liang Jintao*, and Zhou Zhide*. Colorimetric Aptasensor for Sensitive Glypican-3 Detection Based on Hemin-Reduced Oxide Graphene-Platinum@Palladium Nanoparticles With Peroxidase-Like Activity, IEEE Sensors Journal, 2023, 23 (1): 111-118 .
[10] Liang Jintao, Guo Fei, Huang Jiaying, Tan Xiaohong, Sun Lixian*, Zhou Zhide*, Li Guiyin*. An ultrasensitive label-free electrochemical aptasensing platform for Golgi protein-73 detection based on RGO-Fc-Mn3O4 nanocomposites, Microchemical Journal, 193 (2023) 109138.
[11] Zhou Fan, Gao Lin, Cu Shunyan, Tian Jing, Wang Tong, Li Guiyin, Wang Zhongmin, Qin Chaoke, Lin Dahong, Gan Weijiang*, Ran Zhaojin. Exploring the potential of magnetic persimmon tannins-based bio-adsorbent for Cd (II) ions removal from water: Experiment and DFT study, Journal of Water Process Engineering, 56 (2023) 104283.
[12] Li Guiyin, Wu Guangxiong, Yan Ruijie, Li XinHao, Liang Jintao*, Tan Mingxiong*. Zhou Zhide*. Carbon-based light addressable potential sensor based on nitrogen-doped graphene quantum dots for detection of low-density lipoprotein, Microchemical Journal, 196 (2024) 109556.
[13] Liang Jintao, Wu Liang, Wang Liru, Li Guiyin, Zhang Tie, Zhang Yonghuai, and Zhang Jiayang. Determination of difluoromethane (R32) by non-dispersive infrared (NDIR) spectroscopy with temperature compensation by an improved whale optimization algorithm (IWOA), Instrumentation Science & Technology (2023).
2022年
[1] Li Guiyin, Li Wenzhan, Li Shengnan, Li Xinhao,Yao Xiaoqing, Xue Wen, Liang Jintao*, Chen Jiejing*, Zhou Zhide*. A label-free electrochemical aptasensor based on platinum@palladium nanoparticles decorated with hemin-reduced graphene oxide as a signal amplifier for glypican-3 determination, Biomaterials Science, 10 (2022) 6804-6817
[2] Li Guiyin, Xue Yewei, Wang Chaoxian, Li Xinhao, Li Shengnan, Huang Yong*, Zhou Zhide*. Persimmon Tannin-Reduction Graphene Oxide-Platinum-Palladium Nanocomposite Decorated on Screen-Printed Carbon Electrode for Enhanced Electrocatalytic Reduction of Hydrogen Peroxide, Journal of Biomedical Nanotechnology, 18 (2022) 1468-1480
[3] Liu Zhigao,Wang Zhongmin, Gan Weijiang, Liu Songlin, Zhang Jianglin, Ran Zhaojin,Wu Chenxi, Hu Chaohao,Wang Dianhui, Chen Tao, Li Guiyin*. Computational and Experimental Investigation of the Selective Adsorption of Indium/Iron Ions by the Epigallocatechin Gallate Monomer. Materials, 15 (2022) 8251
[4] Xinhao Li,Shengnan Li, Qiuyan Lv,Chaoxian Wang, Jintao Liang*, Zhide Zhou*, Guiyin Li*. Colorimetric biosensor for visual determination of Golgi protein 73 based on reduced graphene oxide-carboxymethyl chitosan-Hemin/platinum@palladium nanozyme with peroxidase-like activity, Microchimica Acta, 189 (2022) 392
[5] Li Guiyin, Chen Wei, Mi Danhong, Wang Bo, Li HaiMei, Wu Guangxiong, Ding Ping*, Liang Jintao*, Zhou Zhide*. A highly sensitive strategy for glypican-3 detection based on aptamer/gold carbon dots/magnetic graphene oxide nanosheets as fluorescent biosensor, Analytical and Bioanalytical Chemistry, 414 (2022):6441-6453
[6] Li Guiyin,Wu Guangxiong, Huang Jindan,Wang Bo, Li HaiMei, Chen Wei, Liang Jintao*,Tan Mingxiong*, Zhou Zhide*. Nanozyme-mediated cascade reaction system for electrochemical detection of 1,5-anhydroglucitol, Bioelectrochemistry, 147 (2022) 108204
[7] Li Shengnan, Li Xinhao, Cao Liping, Wang Chaoxian, Liang Jintao*, Zhou Zhide*, Li Guiyin*. An Ultrasensitive Glypican‑3 Electrochemical Aptasensor Based on Reduced Graphene Oxide-Carboxymethylchitosan -Hemin/Palladium Nanoparticles, Journal of the Electrochemical Society, 169 (2022) 087517
[8] Li Guiyin, Wang Bo, Le Zhao, Shi Xiaohang, Wu Guangxiong, Chen Wei, Sun Lixian*, Liang Jintao*, Zhou Zhide*, Label-free detection of glypican-3 using reduced graphene oxide /polyetherimide/gold nanoparticles enhanced aptamer specific sensing interface on light-addressable potentiometric sensor, Electrochim Acta, 426 (2022) 140808
[9] Li Guiyin,Chen Min,Wang Bo💆🏼♂️,Wang Chaoxian,Wu Guanxiong,Liang Jintao*, Zhou Zhide*, Dual-signal sandwich-type aptasensor based on H-rGO-Mn3O4 nanozymes for ultrasensitive Golgi protein 73 determination. Analytica Chimica Acta, (1221) 2022, 340102
[10] Wang Huixue, Liu Jinya, Chen Wei, Na Jintong, Huang Yong*, Li Guiyin*, A fluorescence aptasensor based on GSH@GQDs and RGO for the detection of Glypican-3, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 270 (2022) 120798