基本情況🙏🏻👰♀️：
李忠貞🧏，廣東茂名人，1990年11月生👮🏻♀️，理學博士♣️🫷🏻，副教授（校內聘）。
聯系方式🔥：電子郵箱🂠：960510784@qq.com
教育背景：
2009.09-2013.06 廣東工業大學🪪，生物工程專業📂，獲工學學士學位
2013.09-2019.06 汕頭大學，海洋生物學專業，獲理學博士學位
工作經歷：
2019.07-2021.06，暨南大學，臨床醫學博士後科研流動站，博士後
2021.07-2024.10👩🏿🔧，珠海市人民醫院🖖🏻，博士後科研工作站，博士後
2024.10至今 熊猫体育👨🏻🦰，生物與食品工程學院，內聘副教授
研究方向💆🏻：
主要從事動物腸道微生物、益生菌、益生元方面的工作🙎♂️📤。
講授課程🧋：
本科生：微生物學
學術兼職🙇🏼：
無。
主要獲獎（自己獲獎或指導學生獲獎）：
第一屆廣東省免疫學會“普銳杯”科普比賽博士後組一等獎🧔🏼♀️，2020年；
汕頭大學第十四屆研究生學術論壇優秀論文獎♎️，2018年；
廣東省大學生實驗室安全與環保知識競賽優勝獎，2011年；
承擔項目👈🏻：
1. 國家自然科學基金青年科學基金項目（編號：32200079）🚀，遲緩埃格特菌誘導焦慮抑郁行為的作用機製及靶向幹預研究🩸，2023.01-2025.12🙇🏽♀️，負責人，在研。
2. 國家自然科學基金面上項目（編號🦦：32070121），錳缺乏通過腸道菌群失衡介導抑郁症及其分子機製，2021.01-2024.12，參與人💇🏽，在研。
3. 國家自然科學基金面上項目（編號：41876152），ECSIT介導的線粒體ROS途徑在擬穴青蟹血淋巴菌群穩態調控中的作用及分子機製🙍🏻♀️♥️，2019.01-2022.12◻️，參與人，結題。
4. 國家自然科學基金面上項目（編號：41641053）➗👐🏼，擬穴青蟹腸道菌群抗病毒感染及其分子機理研究，2017.01-2017.12，參與人，結題🌊。
代表性成果：
1. Li Zhongzhen#, Lei Zhiwei#, Yang Wanying, Jing Chunxia, Sun Xiaolin, Yang Guang, Zhao Xiaozhen, Zhang Mingjiao, Xu Miaomiao, Tang Yuanjia, Wang Qingwen, Zhao Jing, Zhou Zixing, Wen Zihao, Chen Xiaojing, Peng Qinglin, Wang Guochun, Zhang Pingjing, Sun Erwei, Shen Nan, Xu Weiguo*, Li Zhanguo, Yang Hengwen*, Yin Zhinan*. Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus. Parasites & Vectors, 2024, 17(1): 44.
2. Li Zhongzhen, Tran Ngoc Tuan, Ji Peina, Sun Zaiqiao, Wen Xiaobo, Li Shengkang*. Effects of prebiotic mixtures on growth performance, intestinal microbiota and immune response in juvenile chu's croaker, Nibea coibor. Fish & Shellfish Immunology, 2019, 89: 564-573.
3. Li Zhongzhen, Zhang Xinxu, Aweya Jude Juventus, Wang Shuqi, Hu Zhong, Li Shengkang*, Wen Xiaobo. Formulated diet alters gut microbiota compositions in marine fish Nibea coibor and Nibea diacanthus. Aquaculture Research, 2018, 50(1): 126-138.
4. Yan Junjie#, Zeng Yingying#, Guan Zerong#, Li Zhenhua#, Luo Shunchang#, Niu Jie#, Zhao Junzhang#, Gong Haibiao, Huang Ting, Li Zhongzhen, Deng Anyi, Wen Qiong, Tan Jingyi, Jiang Jun, Bao Xiucong, Li Sitao, Sun Guodong, Zhang Min, Zhi Min*, Yin Zhinan*, Sun Wan-Yang*, Li Yi-Fang*, He Rong-Rong*, Cao Guangchao*. Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Reports, 2024, 43(8): 114636.
5. Zhang Ming, Ji Peina, Li Zhongzhen, Sun Zaiqiao, Tran Ngoc Tuan, Li Shengkang*. Catalase regulates the homeostasis of hemolymph microbiota and autophagy of the hemocytes in mud crab (Scylla paramamosain). Aquaculture Reports, 2022, 25: 101237.
6. Tran Ngoc Tuan, Li Zhongzhen, Ma Hongyu, Zhang Yueling, Zheng Huaiping, Gong Yi, Li Shengkang*. Clostridium butyricum: a promising probiotic confers positive health benefits in aquatic animals. Reviews in Aquaculture, 2020, 12(4): 2573-2589.
7. Tran Ngoc Tuan; Tang Yong; Li Zhongzhen, Zhang Ming, Wen Xiaobo, Ma Hongyu, Li Shengkang*. Galactooligosaccharides and resistant starch altered microbiota and short-chain fatty acids in an in vitro fermentation study using gut contents of mud crab (Scylla paramamosain). Frontiers in Microbiology, 2020, 11: 1352.
8. Yang Qiuhua, Lü Yongling, Zhang Ming, Gong Yi, Li Zhongzhen, Tran Ngoc Tuan, He Yüyong, Zhu Chunhua, Lu Yishan, Zhang Yueling, Li Shengkang*. Lactic acid bacteria, Enterococcus faecalis Y17 and Pediococcus pentosaceus G11, improved growth performance, and immunity of mud crab (Scylla paramamosain). Fish & Shellfish Immunology, 2019, 93: 135-143.
9. Tran Ngoc Tuan, Li Zhongzhen, Wang Shuqi, Zheng Huaiping, Aweya Jude Juventus, Wen Xiaobo, Li Shengkang*. Progress and perspectives of short‐chain fatty acids in aquaculture. Reviews in Aquaculture, 2018, 12(1): 283-298.
10. Zhang Xinxu, Wu Huijuan, Li Zhongzhen, Li Yuanyou, Wang Shuqi, Zhu Dashi, Wen Xiaobo, Li Shengkang*. Effects of dietary supplementation of Ulva pertusa and non-starch polysaccharide enzymes on gut microbiota of Siganus canaliculatus. Journal of Oceanology and Limnology, 2017, 36(2): 438-449.
11. Sun Wanwei, Li Zhongzhen, Wang Shasha, Wan Weisong, Wang Shuqi, Wen Xiaobo, Zheng Huaiping, Zhang Yueling, Li Shengkang*. Identification of a novel clip domain serine proteinase (Sp-cSP) and its roles in innate immune system of mud crab Scylla paramamosain. Fish & Shellfish Immunology, 2015, 47(1): 15-27.
12. Wu Huijuan, Sun Lingbin, Li Chuanbiao, Li Zhongzhen, Zhang Zhao, Wen Xiaobo, Hu Zhong, Zhang Yueling, Li Shengkang*. Enhancement of the immune response and protection against Vibrio parahaemolyticus by indigenous probiotic Bacillus strains in mud crab (Scylla paramamosain). Fish & Shellfish Immunology, 2014, 41(2): 156-162.
13. 李升康, 李忠貞, 孫再橋, 黎照熙. 一株具有益生活性的產丁酸菌DG1及其培養方法與應用, 授權發明專利, ZL201910361921.3, 2022/12/20.
14. 李升康, 李忠貞, 紀培娜, 張明. 一株具有益生活性的丁酸梭菌CG3及其培養方法與應用, 授權發明專利, ZL201910361908.8, 2022/12/6.
15. 李升康, 呂永玲, 李忠貞, 劉文華, 胡忠, 溫小波. 一株糞腸球菌Y17及其篩選培養與應用, 授權發明專利, ZL201610547932.7, 2019/9/13.
16. 李升康, 呂永玲, 李忠貞, 劉文華, 胡忠, 溫小波. 一株戊糖片球菌G11及其篩選與應用, 授權發明專利, ZL201610547940.1, 2019/9/13.
